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Localization of manganese superoxide dismutase in the cerebral cortex and hippocampus of Alzheimer-type senile dementia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Miho Takagi, Hitoshi Hattori, Hisashi Matsuzaki, Tetsuya |
| Copyright Year | 1997 |
| Abstract | Manganese-superoxide dismutase (Mn-SOD) was localized in the cerebral cortex and hippocampus of patients with Alzheimer-type senile dementia (ATD) by immunocytochemistry and the relationship of Mn-SOD with two major pathological features of ATD, i.e., senile plaques and neurofibrillar tangles (NFTs), was examined. Many astrocytes in senile plaques exhibited strong immunoreactivity for both Mn-SOD and glial fibrillar acidic protein (GFAP) on serial section analysis. This suggests that Mn-SOD scavenger system is associated with the formation of senile plaques. On the other hand, Mn-SOD immunoreactivity was not significant in NFT-loaded neurons. |
| Starting Page | 1 |
| Ending Page | 5 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 9343989 |
| Journal | Medline |
| Volume Number | 43 |
| Issue Number | 1 |
| Alternate Webpage(s) | http://dlisv03.media.osaka-cu.ac.jp/infolib/user_contents/kiyo/DB00011473.pdf |
| Journal | Osaka city medical journal |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
