NDLI: Green synthesis of folic acid-conjugated gold nanoparticles with pectin as reducing/stabilizing agent for cancer theranostics

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Green synthesis of folic acid-conjugated gold nanoparticles with pectin as reducing/stabilizing agent for cancer theranostics

Content Provider	Semantic Scholar
Author	Devendiran, Raja Modhugoor Chinnaiyan, Senthil Kumar Yadav, Narra Kishore Moorthy, G. K. Ramanathan, Giriprasath Singaravelu, Sivakumar Sivagnanam, Uma Tirichurapalli Perumal, Paramasivan T.
Copyright Year	2016
Abstract	In the present study pectin, a natural polysaccharide was employed for the one pot aqueous synthesis of gold nanoparticles (GNPs). Pectin acted at the same time as both a reducing and stabilizing agent. The formation of pectin reduced GNPs (Pec-GNPs) was confirmed by using a UV-visible spectrophotometer, with a characteristic surface plasmon resonance (SPR) band at 527 nm. EDS analysis proved the presence of gold in the sample. The spherical morphology and crystalline nature of the Pec-GNPs was demonstrated by TEM analysis. The FTIR spectrum revealed the capping of pectin on the surface of the synthesised GNPs. Furthermore, the Pec-GNPs are found to be stable at different pH and electrolytic conditions. In vivo safety of the Pec-GNPs was established through zebra fish toxicity studies. The cationic drug doxorubicin was successfully loaded onto the synthesized anionic Pec-GNPs by an ionic complexation interaction. In vitro release studies confirmed the pH dependent sustained release of the doxorubicin. Doxorubicin loaded Pec-GNPs exhibited enhanced in vitro cytotoxicity on breast cancer cells compared to free doxorubicin, demonstrating that Pec-GNPs are efficient vehicles for the delivery of doxorubicin. Furthermore, chitosan coupled with folic acid (FA) was decorated with Pec-GNPs-DOX as a nanocarrier to improve the targeting and enhance the drug delivery to target cancer tissues by folic acid receptor-mediated endocytosis. It was concluded that the FA@Pec-GNPs-DOX were biocompatible and suitable for anti-cancer drug delivery, and were potentially promising as a new therapeutic system for cancer treatment.
Starting Page	29757
Ending Page	29768
Page Count	12
File Format	PDF HTM / HTML
DOI	10.1039/C6RA01698G
Volume Number	6
Alternate Webpage(s)	http://www.rsc.org/suppdata/c6/ra/c6ra01698g/c6ra01698g1.pdf
Alternate Webpage(s)	https://doi.org/10.1039/C6RA01698G
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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