The Effects of Saline Infusion on Sodium Reabsorption by the Proximal Tubule of the Dog.

Content Provider	Semantic Scholar
Author	Cirksena, W. J.
Copyright Year	1965
Abstract	A depression of sodium reabsorption has recently been shown to occur in the dog nephron after intravenous saline administration. De Wardener, Mills, Clapham, and Hayter (1, 2) and Levinsky and Lalone (3) have demonstrated that the increased sodium excretion can occur despite reduced glomerular filtration rate and in the presence of high levels of circulating adrenal cortical hormones and vasopressin. The natriuresis was also independent of the renal nerves and of changes in the sodium concentration of plasma, plasma proteins, and hematocrit. Such results have suggested that an additional unidentified humoral agent is involved in sodium reabsorption by the tubules. The precise locus of this effect on the tubules has not yet been defined, but several investigators have favored a distal site (4-6). Rector, Van Giesen, Kiil, and Seldin (7), on the other hand, interpreted the increased generation of free water and increased potassium excretion during hypotonic saline infusions as indicating a more proximal site of the diminished sodium reabsorption. The proximal tubule has been considered to reabsorb a constant fraction of the filtrate, a view first offered by Smith (8). Micropuncture studies in the rat proximal tubule by Lassiter, Mylle, and Gottschalk and by Giebisch, Klose, and Windhager (9, 10) were largely in accord with this
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Alternate Webpage(s)	http://dm5migu4zj3pb.cloudfront.net/manuscripts/105000/105223/JCI65105223.pdf
PubMed reference number	14328393v1
Volume Number	44
Journal	The Journal of clinical investigation
Language	English
Access Restriction	Open
Subject Keyword	Depressive disorder Epinephrine Kidney Glomerulus Kidney Tubules, Proximal Micropunctures Natriuresis Nephrons Nerve Potassium Renal Tubular Acidosis, Type II Sodium Vasopressins glomerular filtration
Content Type	Text
Resource Type	Article