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Paradoxical reaction of blood pressure on sleep apnoea patients treated with Positive Airway Pressure.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Loureiro, Carla Chaves Drummond, Marta Winck, J. C. Almeida, J. |
| Copyright Year | 2011 |
| Abstract | INTRODUCTION Obstructive Sleep Apnoea Syndrome (OSAS) patients may develop hypertension and Positive Airway Pressure (PAP) is an effective treatment in blood pressure (BP) control. OBJECTIVES Analyse a hypertensive OSAS population with unexpected BP rise after PAP usage and verify correlations between BP rise, either with OSAS severity index or nocturnal ventilatory support compliance. METHODS Descriptive, retrospective analysis of 30 patients with PAP treated OSA, for one year, on average, and with previous controlled hypertension, who developed a rise in BP, defined as augmentation of > 5 mmHg in systolic (SBP) and/or diastolic BP (DBP), after PAP usage. Co-relational analysis of BP increase, with OSAS severity indexes and therapy compliance, using Pearson coefficient. RESULTS Of 508 consecutive patients followed in our Department, treated with nocturnal ventilatory support, 30 evolved with BP rise after initiating treatment (age 58 ± 10.8 years; Apnoea-Hypopnoea Index [AHI], 46.1 ± 18.68). After PAP usage, mean blood pressure (MBP), Systolic BP (SBP) and Diastolic BP (DBP) variation was 16 ± 15 mmHg, 20 ± 25 mmHg and 6 ± 19.4 mmHg, respectively. No patient showed significant BMI increase. Epworth Sleepiness Scale (ESS) value decreased 8.9 ± 5.48 points. MBP, SBP and DBP variations were not correlated with P90/P95, residual AHI, leaks or PAP compliance. CONCLUSIONS No specific characteristics were identified in the group who developed a rise in BP with PAP usage. No correlations were found between rises in BP and OSAS severity indexes or PAP compliance. Neither BMI nor variation in wakefulness status explained the rise in BP. Studies relate polymorphisms of β1-adrenoreceptors with different BP responses to ventilatory support. More studies are needed to clarify the cause of this paradoxical response. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.elsevier.pt/en/revistas/revista-portuguesa-pneumologia-320/pdf/S2173511511700148/S300/ |
| PubMed reference number | 21477566v1 |
| Volume Number | 17 |
| Issue Number | 2 |
| Journal | Revista portuguesa de pneumologia |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biomechanical compliance Description Diastole Diastolic blood pressure Epworth Sleepiness Scale Questionnaire Genetic Polymorphism Hematological Disease Hypertensive disease Index Intracranial Hypertension Intravascular mean:Pressure:Point in time:Arterial system:Quantitative Patients Sleep Apnea Syndromes Sleep Apnea, Obstructive Sleep Wake Disorders Somnolence Systolic Pressure TFRC protein, human Visual Analog Pain Scale Wakefulness torr |
| Content Type | Text |
| Resource Type | Article |
