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Impairment of the production of delta sleep in anorectic adolescents.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nobili, Lino Baglietto, Maria Giuseppina Beelke, Manolo E. Carli, Fabrizio De Comite, Raffaella Di Fiocchi, Isabella Rizzo, Pierpaolo Veneselli, E. Savoini, Margherita Zanotto, Elisabetta Ferrillo, Franco |
| Copyright Year | 2004 |
| Abstract | OBJECTIVE Total sleep time and slow-wave sleep (SWS) are frequently reported to be reduced in anorectics. A preliminary study showed that slow-wave activity (SWA, 0.5-4.5 Hz) is decreased in anorectic adolescents. The present study investigates whether this reduction is the result of the increased sleep fragmentation or is dependent on an intrinsic weakness of SWA-producing mechanisms. DESIGN Statistical analysis of spectral electroencephalogram data recorded during sleep from a group of anorectics and a control group. SETTING Polysomnographic data were recorded in single rooms in the hospital for 1 night following an adaptation night. PARTICIPANTS 20 adolescent anorectic girls (13.9 +/- 2.0 years) and 12 age-matched control subjects. INTERVENTIONS Refeeding and psychotherapy. MEASUREMENTS AND RESULTS Anorectics had an increase of wakefulness after sleep onset, a higher number of arousals, and a reduction of SWS and SWA during total sleep time. No relationship between the reduction of SWA and duration of illness was found, while a relationship between SWA decrease and the level of emaciation (body mass index) was present. The analysis limited to the first non-rapid eye movement sleep cycle did not show any difference between the 2 groups in the number of awakenings and arousals. Nevertheless, anorectics showed a reduction of SWS and SWA. CONCLUSIONS Sleep of anorectic patients seems to be characterized by an impairment of SWA-producing mechanisms independent of the increased sleep fragmentation. This is probably related to the primary pathophysiologic characteristics of the illness but could also reflect secondary functional and anatomic alterations of the brain. |
| Starting Page | 1039 |
| Ending Page | 1044 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.journalsleep.org/Articles/270814.pdf |
| PubMed reference number | 15683147v1 |
| Volume Number | 27 |
| Issue Number | 8 |
| Journal | Sleep |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acclimatization Adolescent (age group) Anorexia Appetite Depressants Arousal Body Dysmorphic Disorders Electroencephalography Emaciation Eye Abnormalities Female child Hertz (Hz) Hypersomnia ITSN2 gene Illness (finding) Patients Psychotherapy Sleep Apnea Syndromes Sleep, REM Sleep, Slow-Wave Wakefulness |
| Content Type | Text |
| Resource Type | Article |
