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476 Glucosamine Sulfate and Chondroitin Sulfate: Their Effect on Chondrocyte Proteome
| Content Provider | Semantic Scholar |
|---|---|
| Author | Calamia, Valentina Ruiz-Romero, Cristina Carreira, Vanessa Mateos, Jesús Cillero-Pastor, Berta Montell, Eulàlia Vergés, J. Galdo, Francesca Blanco, Francisco J. |
| Copyright Year | 2008 |
| Abstract | and connective tissue growth factor. Il-1 stimulated release of the cartilage degeneration marker MMP-3, as well as proteins with uncharacterized roles in cartilage pathology, such as neutrophil gelatinase-associated lipocalin. RetA stimulated release of extracellular matrix proteins COMP, link protein and matrilin-3 into the media, accompanied by dramatic reduction in corresponding mRNA transcripts levels. Gelsolin, implicated in cytoskeletal reorganization in arthritic synovial fibroblasts but not previously associated with cartilage pathology, was regulated by Il-1 and RetA. Conclusions: This first analysis of mouse cartilage degradation and protein release using proteomics has identified proteins and fragments, some of which represent novel candidate biomarkers for cartilage degradation. Applying these proteomic techniques to wild-type and geneticallymodified mouse cartilage will provide insights into mechanisms of cartilage degeneration. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S1063-4584(08)60516-6 |
| Volume Number | 16 |
| Alternate Webpage(s) | https://core.ac.uk/download/pdf/82358490.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/S1063-4584%2808%2960516-6 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
