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Anti Cancer Activity of Active Substances from Mangosteen pericarp (Garcinia mangostana Linn) against T47 D Cell Lines
| Content Provider | Semantic Scholar |
|---|---|
| Author | Rofida, Siti Sukardiman, Sukardiman Widyawaruyanti, Aty Arifianti, Lusiana |
| Copyright Year | 2017 |
| Abstract | Background: Garcinia mangostana Linn (Guttiferae) or commonly know as mangosteen has been reported scientifically as anticancer. In developing a pericarp of G.mangostana as the anticancer phytopharmaceutical product, bioassay-guided fractionation approach was chosen to get active substances to be used as raw material breast-cancer drugs. Objectives:The aim of this study is to get the anticancer substances from the pericarp of G.mangostana that are active against breast cancer cells T47D. Method: Separation of active substances was carried out by column chromatography techniques. Based on the principle of bioassay-guided fractionation, a cytotoxicity assay of ethanolic extract and fractions was performed against T47D human breast cancer cell lines. Results:Cytotoxicity assay of the extract, fraction 2, subfraction 2.2, subfraction 2.2.4, and subfraction 2.2.4.4 provided IC50 values 8.96 ug/mL; 1.80 ug/mL; 1.76 ug/mL; 1.12 ug/mL; and 6.93 ug/mL respectively |
| File Format | PDF HTM / HTML |
| DOI | 10.2991/hsic-17.2017.43 |
| Alternate Webpage(s) | https://download.atlantis-press.com/article/25885859.pdf |
| Alternate Webpage(s) | https://doi.org/10.2991/hsic-17.2017.43 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
