Loading...
Please wait, while we are loading the content...
SIDS INITIAL ASSESSMENT PROFILE CAS No . 335-671 3825-26-1 Chemical Name Perfluorooctanoic Acid ( PFOA ) Ammonium Perfluorooctanoate ( APFO ) Structural formula COOH
| Content Provider | Semantic Scholar |
|---|---|
| Copyright Year | 2008 |
| Abstract | Several epidemiology and medical surveillance studies have been conducted on workers employed at various APFO manufacturing sites in the U.S. Most of the studies were cross-sectional and focused primarily on males. A retrospective cohort mortality study demonstrated a statistically significant association between prostate cancer mortality and employment duration in the chemical facility of a plant that manufactures PFOA. However, in an update to this study in which more specific exposure measures were used, a significant association for prostate cancer was not observed. Other mortality studies lacked adequate exposure data which could be linked to health outcomes. A study which examined hormone levels in workers reported an increase in estradiol levels in workers with the highest PFOA serum levels; however, these results may have been confounded by body mass index. Cholesterol and triglyceride levels in workers were positively associated with PFOA exposures, which is inconsistent with the hypolipidemic effects observed in rat studies. A statistically significant positive association was reported for PFOA and T3 levels in workers but not for any other thyroid hormones. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://hpvchemicals.oecd.org/ui/handler.axd?id=c4b4700f-48f3-4aca-b6a7-6606b1a4fa48 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
