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Clinical and genetic features of therapy-related myeloid neoplasms after chemotherapy for acute promyelocytic leukemia.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Imagawa, Jun Harada, Yuka Shimomura, Takeshi Tanaka, Hideo Okikawa, Yoshiko Hyodo, Hiromi Kimura, Atutaka Harada, Hironori |
| Copyright Year | 2010 |
| Abstract | Acute promyelocytic leukemia (APL) is a highly curable disease with excellent complete remission and long-term survival rates. However, the development of therapy-related myeloid neoplasms (t-MN) is being reported with increasing frequency in patients successfully treated for APL. We attempted to clarify the different clinical features and hematologic findings between t-MN and relapse cases, and to identify gene alterations involved in t-MN. We compared 10 relapse and 11 t-MN cases that developed in 108 patients during their first complete remission from APL. At APL diagnosis, t-MN patients had lower white blood cell counts than did relapse patients (P = .048). Overall survival starting from chemotherapy was significantly worse in t-MN patients than in relapse patients (P = .022). The t-MN cases were characterized as CD34(+)/HLA-DR(+) and PML-RARA(-), and 4 RUNX1/AML1 mutations were detected. T-MN is easily distinguished from APL relapse by evaluating these hematologic features, and it may originate from primitive myeloid cells by chemotherapy-induced RUNX1 mutations. |
| Starting Page | CD004380 |
| Ending Page | CD004380 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bloodjournal.org/content/bloodjournal/116/26/6018.full.pdf?sso-checked=true |
| PubMed reference number | 20861459v1 |
| Alternate Webpage(s) | https://doi.org/10.1182/blood-2010-06-289389 |
| DOI | 10.1182/blood-2010-06-289389 |
| Journal | Blood |
| Volume Number | 116 |
| Issue Number | 26 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Acute Promyelocytic Leukemia Attempt Blood Cell Count Hematology (discipline) Leukemia, Myelocytic, Acute Leukocytes Leukoencephalopathy, Progressive Multifocal Mutation Neoplasms Patients Prostatic Neoplasms, Castration-Resistant acute myeloid leukemia 1 protein |
| Content Type | Text |
| Resource Type | Article |
