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Association of rotavirus strains and severity of gastroenteritis in Indian children
| Content Provider | Semantic Scholar |
|---|---|
| Author | Saluja, Tarun Dhingra, Mandeep Singh Sharma, Shiv Dutt Gupta, Madhu Kundu, Ritabrata Kar, Sonali Dutta, Ashok K. Silveira, Maria Pedro Singh, Jai Veer Kamath, Veena G. Chaudhary, Anurag Rao, Venkateswara K. Ravi, Mandyam Dhati Murthy, Kesava Arumugam, Rajesh Moureau, Annick Prasad, Rajendra Patnaik, Badri Narayan |
| Copyright Year | 2017 |
| Abstract | Rotavirus is the leading cause of severe and dehydrating diarrhea in children aged under 5 years. We undertook this hospital-based surveillance study to examine the possible relationship between the severity of diarrhea and the various G-group rotaviruses circulating in India. Stool samples (n = 2,051) were systematically collected from 4,711 children aged <5 years admitted with severe acute gastroenteritis to 12 medical school centers from April 2011 to July 2012. Rotavirus testing was undertaken using a commercially available enzyme immunoassay kit for the rotavirus VP6 antigen (Premier Rotaclone Qualitative ELISA). Rotavirus positive samples were genotyped for VP7 and VP4 antigens by reverse-transcription polymerase chain reaction at a central laboratory. Of the stool samples tested for rotavirus antigen, 541 (26.4%) were positive for VP6 antigen. Single serotype infections from 377 stool samples were compared in terms of gastroenteritis severity. Among those with G1 rotavirus infection, very severe diarrhea (Vesikari score ≥ 16) was reported in 59 (33.9%) children, severe diarrhea (Vesikari score 11-15) in 104 (59.8%), moderate (Vesikari score 6-10) and mild diarrhea (Vesikari score 0-5) in 11 (6.3%). Among those with G2 infection, very severe diarrhea was reported in 26 (27.4%) children, severe diarrhea in 46 (48.4%), and moderate and mild diarrhea in 23 (24.2 %). Among those with G9 infection, very severe diarrhea was reported in 47 (54.5%) children, severe diarrhea in 29 (33.6%), and moderate and mild diarrhea in 10 (11.9%). Among those with G12 infection, very severe diarrhea was reported in 9 (40.9%) children and severe diarrhea in 13 (59.1%). The results of this study indicate some association between rotavirus serotypes and severity of gastroenteritis. |
| Starting Page | 711 |
| Ending Page | 716 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| PubMed reference number | 27686522 |
| Alternate Webpage(s) | https://doi.org/10.1080/21645515.2016.1238994 |
| DOI | 10.1080/21645515.2016.1238994 |
| Journal | Human vaccines & immunotherapeutics |
| Volume Number | 13 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Borg Category-Ratio 10 Perceived Exertion Score 7 CDISC SEND Severity Terminology CNS disorder Diarrhea Enzyme Immunoassay Enzyme-Linked Immunosorbent Assay Feces Fifty Nine Gastroenteritis HIV Infections Immunoassay method Mast/Stem Cell Growth Factor Receptor Kit, human Medical Surveillance Polymerase Chain Reaction Rotavirus Infections Serotype Surgical Wound Infection |
| Content Type | Text |
| Resource Type | Article |
