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Morphine induced increases in the incorporation of 3H-thymidine into brain striatal DNA
| Content Provider | Semantic Scholar |
|---|---|
| Author | Messing, Rita B. Dodge, Clara Waymire, Jack C. Lynch, Gary S. Deadwyler, Sam A. |
| Copyright Year | 1979 |
| Abstract | 3H-thymidine uptake into DNA fractions of rat brain regions was measured following in vivo administration of (methyl-3H)-thymidine and morphine. Acute morphine administration (10 mg/kg; 30 min prior to 3H-thymidine) increased incorporation of 3H-thymidine into DNA of rat striatum. This effect was antagonized by naloxone (1 mg/kg). Further, the observed change in incorporation of 3H-thymidine into DNA in striatum could not be accounted for by differences in the local availability of the label in morphinized rats. An autoradiographic study revealed that the 3H-thymidine was localized in nuclei in cells of the sub-ependymal layer lining the lateral ventricles, an area of glial cell proliferation in adult rats. No change in 3H-thymidine incorporation into DNA was observed in any area of the brain in morphine-addicted rats or in rats undergoing naloxone-precipitated withdrawal. The results indicate that opiates may induce permanent anatomical changes in the brain, including alterations of neuroglial interactions. |
| Starting Page | 615 |
| Ending Page | 619 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0361-9230(79)90102-3 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0361923079901023 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0361923079901023?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 487217 |
| Alternate Webpage(s) | https://doi.org/10.1016/0361-9230%2879%2990102-3 |
| Journal | Medline |
| Volume Number | 4 |
| Journal | Brain Research Bulletin |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
