NDLI: Deformability Based Separation of Circulating Tumor Cells from Patients with Castrate Resistant Prostate Cancer

Content Provider	Semantic Scholar
Author	Park, Sunyoung Jin, Chao Ang, Richard Duffy, Simon P. Abdi, Hamid Black, Peter Ma, Hongshen
Copyright Year	2014
Abstract	We present a deformability based cell separation device created using the microfluidic ratchet mechanism to separate live circulating tumor cells from whole blood. This device is capable of log-4 depletion of leukocytes when tested using cultured cancer cells doped into whole blood. To evaluate this device, we separated and enumerated CTCs from 33 patients with castrate resistant prostate cancer and 6 healthy controls, and compared the results in simultaneous experiments performed using the CellSearch system, the current commercial standard. The CTC capture rate is significantly higher for our device, which detected >5 CTCs in 75.5% of patients with an average count of 235, while the CellSearch system detected >5 CTCs in 36.3% of patients with an average count of 104.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.rsc.org/images/loc/2014/PDFs/Papers/029_0702.pdf
Alternate Webpage(s)	http://ampel.sites.olt.ubc.ca/files/2014/05/Chao-Jin-and-Emily-Park-DEFORMABILITY-BASED-SEPARATION-OF-CIRCULATING-TUMOR-CELLS-FROM-PATIENTS-WITH-CASTRATE-RESISTANT-PROSTATE-CANCER1.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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