α-Adrenergic influences on neuronal responses to visceral afferent input in the nucleus tractus solitarius

Content Provider	Semantic Scholar
Author	Feldman, Peter D. Felder, Robert B.
Copyright Year	1989
Abstract	Studies were made of the effects of the α1-adrenoceptor agonist methoxamine on spontaneous and synaptically evoked activity in the solitary tract nucleus in isolated, perfused slices of the brain of the rat and those effects were compared to the effects of the α2-agonist clonidine. Methoxamine had no effect on the spike activity of 7 out of 8 spontaneously firing neurones, with no response to electrical stimulation of the solitary tract. Among neurones that responded to tract stimulation, those which were otherwise silent (N = 38) showed a decrease of responsiveness to tract input during the infusion of methoxamine, whereas those with spontaneous activity (N = 10) showed mostly increases of both firing rate and responsiveness. The effects of activation of α2-receptors on responsiveness to tract stimulation were the opposite of previously demonstrated effects of activation of α2-receptors, and these opposing effects could be demonstrated in the same neurone. These results suggest that the transmission of visceral sensory information within the nucleus tractus solitarius may be controlled by opposing α1- and α2-receptor-mediated neural systems.
Starting Page	1081
Ending Page	1087
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/0028-3908(89)90121-4
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0028390889901214
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0028390889901214?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0028-3908%2889%2990121-4
Volume Number	28
Journal	Neuropharmacology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article