Blood Loss. for Patients with Hypoferremia Due Blood 8 J a N U a R Y 2 0 0 9 I V O L U M E 1 1 3 , N U M B E R 2

Content Provider	Semantic Scholar
Author	Baum Socié, Gérard Louis, Saint
Abstract	to the anemia of chronic disease, would cur-cumin exacerbate anemia, or would its effects on hepcidin alter the effects of hepcidin on other aspects of erythropoiesis in a favorable direc-tion? 6 Like much good research, the current report answers some questions while giving rise to new ones. Aggarwal BB. Curcumin as " Cure-cumin " : from kitchen to clinic.teraction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models. The value of a complete blood count in predicting cancer of the colon.bial peptide transgenic mice exhibit features of the anemia of inflammation. In this issue of Blood, Paczesny and colleagues describe a set of 4 serum proteins that may help to confirm the diagnosis of acute GVHD and seem to be associated with worse survival independently of GVHD grade. A cute graft-versus-host disease (GVHD), the main complication of allogeneic he-matopoietic cell transplantation, is mainly diagnosed clinically and can be confirmed by biopsy of 1 of the 3 target organs (skin, gastro-intestinal tract, or liver). The severity of acute GVHD is graded clinically from I to IV, with increased mortality rates in severe GVHD (grades II-IV). Although multiple blood proteins have been described as potential biomarkers in previous smaller studies, no single protein or panel has emerged with sufficient specificity and sensitivity to enter clinical use. More recently , mass spectrometric profiling 1-3 of urine and serum were reported to demonstrate the presence of spectral patterns associated with GVHD, but these approaches do not identify specific proteins. In this issue of Blood, Paczesny et al aimed to isolate candidate proteins using high-throughput assays on a large number of patient samples, and to determine their significance with respect to patient outcome. They screened plasma with antibody microarrays for 120 proteins in a discovery set of 42 transplan-tation patients that revealed 8 potential bi-omarkers for diagnostic of GVHD. Using enzyme-linked immunosorbent assays (ELISA), they then measured the levels of these biomarkers in samples from more than 400 transplantation patients divided into training and validation sets. Statistical analysis of these 8 proteins determined a panel of 4 proteins (IL-2-receptor–alpha, TNF-receptor-1, IL-8, and hepatocyte growth factor) that discriminated patients with and without GVHD. In patients with GVHD, Cox regression analysis revealed that the biomarker panel predicted survival independently of GVHD severity. This study is a major achievement in the field and brings proteomics nearly from the bench to the bedside. …
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