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The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ma, Chaoyong Zhou, Ying Beachy, Philip A. Moses, Kevin |
| Copyright Year | 1993 |
| Abstract | Cell-type specification in the Drosophila compound eye begins at the morphogenetic furrow. The furrow sweeps across the developing eye epithelium and is coincident with four classes of cellular events: coordinated changes in cell shape, changes in gene expression, synchronization of the cell cycle, and the specification of a regular array of ommatidial founder cells. The molecular mechanisms that induce these events in the developing eye have hitherto been unknown. We identify here a gene specifically required for furrow progression, hedgehog (hh). We show that hh expression posterior to the morphogenetic furrow is continuously required for its progression. We propose that forward diffusion of hh protein induces anterior cells to enter the furrow. |
| Starting Page | 927 |
| Ending Page | 938 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0092-8674(93)90536-Y |
| PubMed reference number | 8252628 |
| Journal | Medline |
| Volume Number | 75 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/009286749390536Y |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/009286749390536Y?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0092-8674%2893%2990536-Y |
| Journal | Cell |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
