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Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Smolders, Joost Thewissen, Mariëlle Theunissen, Ruud Peelen, Evelyn Damoiseaux, J. H. |
| Copyright Year | 2011 |
| Abstract | An impaired vitamin D (vit-D) processing by immune cells of relapsing remitting multiple sclerosis (RRMS) patients may increase their vulnerability for a poor vit-D status. We assessed with qPCR the expression of vit-D related genes in PBMC and CD4+ T-cells. Gene expression profiles of vit-D receptor (VDR), CYP27B1 and CYP24A1 did not differ between RRMS patients and healthy controls. Interestingly, more VDR expression in PBMC correlated with less circulating IFN-γ+ CD4+ T-cells. Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4+ T-cell compartment. |
| Starting Page | 91 |
| Ending Page | 97 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.jneuroim.2011.03.012 |
| PubMed reference number | 21507492 |
| Journal | Medline |
| Volume Number | 235 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0165572811000968 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0165572811000968?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.jneuroim.2011.03.012 |
| Journal | Journal of Neuroimmunology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
