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Adenosine enhances intracellular Ca2+ mobilization in conjunction with metabotropic glutamate receptor activation by t-ACPD in cultured hippocampal astrocytes
| Content Provider | Semantic Scholar |
|---|---|
| Author | Ogata, T. Nakamura, Yoichi Tsuji, Koji Shibata, Taiho Schubert, Peter N. |
| Copyright Year | 1994 |
| Abstract | 2Cl-Adenosine, a non-metabolized adenosine agonist, enhanced the increase in intracellular Ca2+ concentration ([Ca2+]i) in cultured hippocampal astrocytes induced by (+-)-1-aminocyclopentane-trans-1,3-dicarboxylic acid (t-ACPD), a metabotropic glutamate agonist. In the absence of 2Cl-adenosine, the half effective concentration (EC50) of t-ACPD was about 80 microM. On the other hand, in the presence of 1 microM 2Cl-adenosine, the EC50 of t-ACPD shifted to about 5 microM, although the maximum [Ca2+]i did not change. The synergistic effect of 2Cl-adenosine with t-ACPD on [Ca2+]i elevation was not inhibited by the elimination of extracellular Ca2+, but was inhibited by A1-specific adenosine antagonists. These results indicate that adenosine can act via the A1 receptor as an endogenous co-activator of the metabolic processes induced by metabotropic glutamate receptor activation. |
| Starting Page | 5 |
| Ending Page | 8 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(94)90225-9 |
| PubMed reference number | 8041512 |
| Journal | Medline |
| Volume Number | 170 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394094902259 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394094902259?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2894%2990225-9 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
