NDLI: Cerebral Cortex Synaptic Heavy Mitochondria May Represent the Oldest Synaptic Mitochondrial Population: Biochemical Heterogeneity and Effects of L-Acetylcarnitine

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Cerebral Cortex Synaptic Heavy Mitochondria May Represent the Oldest Synaptic Mitochondrial Population: Biochemical Heterogeneity and Effects of L-Acetylcarnitine

Content Provider	Semantic Scholar
Author	Battino, Maurizio Antonio Quiles, José Luis Huertas, Jesús R. Mataix, Jesús Villa, Roberto Federico Gorini, Antonella
Copyright Year	2000
Abstract	The microheterogeneous nature of intrasynaptic mitochondria has been demonstrated and iswidely accepted. However, evidence is still lacking about the role played by the differentintrasynaptic mitochondrial subpopulations. The data obtained support the hypothesis that“heavy” mitochondria could represent old mitochondrial populations: in fact, in addition tothe well known impairment of typical mitochondrial functions, they possess the highest levelsof hydroperoxides and their fatty acids pattern is completely modified. The qualitative andquantitative fatty acid modifications suffered by these organelles deeply altered theirprotein/lipid ratio, thus modifying their mode of action. The present work also collects a large bodyof evidence that a subchronic L-acetylcarnitine treatment in 28 days does not structurallyaffect both nonsynaptic and intrasynaptic mitochondria of normal rat in a“steady-state”metabolic condition.
Starting Page	163
Ending Page	173
Page Count	11
File Format	PDF HTM / HTML
DOI	10.1023/A:1005559930210
PubMed reference number	11768749
Journal	Medline
Volume Number	32
Alternate Webpage(s)	http://hera.ugr.es/doi/1501647x.pdf
Alternate Webpage(s)	https://doi.org/10.1023/A%3A1005559930210
Journal	Journal of bioenergetics and biomembranes
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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