Loading...
Please wait, while we are loading the content...
Similar Documents
From vessel sprouting to normalization: role of the prolyl hydroxylase domain protein/hypoxia-inducible factor oxygen-sensing machinery.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Coulon, Cathy Georgiadou, Maria Roncal, Carmen Bock, Katrien De Langenberg, Tobias M. J. Carmeliet, Peter |
| Copyright Year | 2010 |
| Abstract | The accepted model of vessel branching distinguishes several endothelial cell fates. At the forefront of a vessel sprout, "tip cells" guide the sprouting vessel toward an angiogenic stimulus. Behind the tip, "stalk cells" proliferate to elongate the vessel branch and create a lumen. In mature vessels, endothelial cells acquire a streamlined shape to optimally conduct blood flow. For this purpose, endothelial cells switch to the "phalanx" cell fate, which is characterized by quiescent and nonproliferating cells aligned in a tight cobblestonelike layer. Vessel maturation also requires the recruitment of mural cells (ie, smooth muscle cells and pericytes). These cell fates are often altered in pathological conditions, most prominently during the formation of tumor vasculature. Given the essential role of hypoxia as the driving force for initiating angiogenesis, it is not surprising that the hypoxia-sensing machinery controls key steps in physiological and pathological angiogenesis. |
| Starting Page | 81 |
| Ending Page | 89 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/30/12/2331.full.pdf?download=true |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/30/12/2331.full.pdf |
| PubMed reference number | 20966400v1 |
| Alternate Webpage(s) | https://doi.org/10.1161/ATVBAHA.110.214106 |
| DOI | 10.1161/atvbaha.110.214106 |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Volume Number | 30 |
| Issue Number | 12 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Alignment Angiogenic Process Biologic Development Blood Vessel Tissue Endothelial Cells Hypoxia Mixed Function Oxygenases Neoplasms Oxygen Pathologic Neovascularization Pericytes Phalanx Unspecified Procollagen-Proline Dioxygenase Smooth muscle (tissue) Structure of lumen of body system |
| Content Type | Text |
| Resource Type | Article |
