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Development of an in-vitro animal model to evaluate novel pharmaceutical approaches to ded management
| Content Provider | Semantic Scholar |
|---|---|
| Author | Menduni, Francesco |
| Copyright Year | 2019 |
| Abstract | In the ophthalmic field, multifactorial pathologies such as Dry Eye Disease (DED) and cataract are largely studied in living animal models that can fail to precisely mirror the complexity of these conditions in humans. Recent advances in biomedical technologies have improved the reliability of in-vitro/ex-vivo animal alternatives, and to date, the corneal and crystalline lens tissue have been independently maintained physiologicallystable for 10 days. This thesis details the development of a novel and complete ex-vivo anterior eye model, which is capable of sustaining both the cornea and crystalline lens in a physiologically stable state in loco for 7 days. The platform is based on porcine eyes, which represent a high quality and reliable human tissue source substitute, and being slaughterhouse waste, also perfectly align the project with the 3Rs principle of replacing, refining and reducing living animal experimentation... |
| Starting Page | 1 |
| Ending Page | 1 |
| Page Count | 1 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://eprints.ucm.es/57372/1/T41399.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
