NDLI: Pegylated liposomal doxorubicin in the treatment of primary cutaneous T-cell lymphomas.

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Pegylated liposomal doxorubicin in the treatment of primary cutaneous T-cell lymphomas.

Content Provider	Semantic Scholar
Author	Pulini, Stefano Rupoli, Serena Goteri, Gaia Pimpinelli, Nicola Alterini, Renato Tassetti, Angela Scortechini, Anna Rita Offidani, Massimo Mulattieri, Simonetta Stronati, Andrea Brandozzi, Giuliano Giacchetti, Alfredo Mozzicafreddo, Giorgio Ricotti, Giuseppe Filosa, Giorgio Bettacchi, Alberta Simonacci, Marco Novelli, Nicolino Leoni, Pietro
Copyright Year	2007
Abstract	Pegylated liposomal doxorubicin (Peg-Doxo) is a promising drug for advanced/recalcitrant primary cutaneous T-cell lymphomas (CTCLs). This prospective phase II trial enrolled 19 patients. We observed overall and complete response rates of 84.2% and 42.1% (with no significant differences between stage I-IIA and IIB-IV patients), and 11% grade III/IV toxicity. After a maximum 46 month-follow-up, median overall (OS), event-free (EFS) and progression-free (PFS) survival were 34, 18 and 19 months. OS, EFS and PFS rates at 46 months were 44%, 30% and 37% respectively. Peg-Doxo seems to be an active and safe principle that should be used in plurirelapsed, early stage-MF and in combination with other chemotherapeutic agents in advanced and aggressive CTCLs.
File Format	PDF HTM / HTML
DOI	10.3324/haematol.10879
PubMed reference number	17488695
Journal	Medline
Volume Number	92
Issue Number	5
Journal	Haematologica
Alternate Webpage(s)	http://www.haematologica.org/content/haematol/92/5/686.full.pdf
Alternate Webpage(s)	https://doi.org/10.3324/haematol.10879
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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