NDLI: Contrast-enhanced multiple-phase imaging features of intrahepatic mass-forming cholangiocarcinoma and hepatocellular carcinoma with cirrhosis: A comparative study

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Contrast-enhanced multiple-phase imaging features of intrahepatic mass-forming cholangiocarcinoma and hepatocellular carcinoma with cirrhosis: A comparative study

Content Provider	Semantic Scholar
Author	Chen, Ying Shen, Ke-Ren Zhu, Xiu-Liang Lu, Chen-Ying Li, Qing-Hai Han, Shu-Gao Fu, Yan-Biao Xu, Xiu-Fang Yu, Ri-Sheng
Copyright Year	2017
Abstract	The intrahepatic mass-forming cholangiocarcinoma (IMCC) is frequently misdiagnosed as hepatocellular carcinoma (HCC) in patients with cirrhosis, by numerous radiologists and clinical doctors, which results in the incorrect therapeutic treatment. A retrospective case-control study was conducted, and the contrast-enhanced multiple-phase (CEMP) computed tomography (CT) and magnetic resonance imaging (MRI) findings of 22 pathologically confirmed IMCC patients and 22 HCC controls with underlying liver cirrhosis were analyzed at the present hospital, from January 2010 to December 2015. In addition, serum tests were conducted and clinical symptoms of patients evaluated. A statistical analysis revealed that the enhancement pattern, signal on MRI delayed phase (P<0.001), maximum diameter, capsule retraction, portal vein invasion, bile duct dilation and abdominal lymphadenectasis characteristics were different between IMCC and HCC patients with cirrhosis. On CEMP CT and MRI analysis, the most frequently occurring enhancement patterns of IMCC were progressive patterns (P=0.001 or P<0.001). Conversely, the most frequently occurring enhancement patterns present in HCC were the washout patterns (P<0.001). Therefore, the diagnosis of IMCC in cirrhotic patients should be verified with CEMP CT and MRI analysis for the future, to determine presence or absence of progressive and/or peripheral rim-like enhancement, a hyperintensive delayed phase with capsule retraction, portal vein invasion, bile duct dilation, abdominal lymphadenectasis and increased levels of CA199.
Starting Page	4213
Ending Page	4219
Page Count	7
File Format	PDF HTM / HTML
DOI	10.3892/ol.2017.6656
PubMed reference number	28943929
Journal	Medline
Volume Number	14
Journal	Oncology letters
Alternate Webpage(s)	https://www.spandidos-publications.com/ol/14/4/4213/download
Alternate Webpage(s)	https://doi.org/10.3892/ol.2017.6656
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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