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Delivering life's blood: emerging technologies, current opportunities and challenges
| Content Provider | Semantic Scholar |
|---|---|
| Author | Khademhosseini, Ali Vunjak-Novakovic, Gordana |
| Copyright Year | 2014 |
| Abstract | Engineering functional tissue constructs with clinically relevant dimensions faces a fundamental challenge of exchanging nutrients and oxygen to satisfy their metabolic needs. A viable strategy for vascularization is critical for engineering viable tissues and organs [1]. Vascularization also plays an important role in the initiation and progression of many pathologies such as cancer [2] and cardiovascular disease [3]. Vascularization is an area where tissue engineering, an inherently multidisciplinary field, can greatly benefit from chemical engineering. The strength of chemical engineers in process design has led to the development of novel biomaterials that can be mechanically and chemically tailored to mimic the extracellular matrix in native tissues [4], and in some cases induce the formation of vascular network. Considerable amount of work has been devoted to the incorporation of growth factors within these biomaterials to induce angiogenesis, in vitro and following implantation. Incorporation of microcirculation within engineered tissues is another crucial parameter for establishing functional vascular supply of oxygen and nutrients [5]. The knowledge of bioreactor design offered by chemical engineers combined with the emergence of microtechnologies has enabled the fabrication of perfusable microscale conduits within biocompatible scaffolds. This strategy allows control of the architecture of the microvascular network and enables immediate perfusion of the scaffolds. |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.coche.2014.01.003 |
| Volume Number | 3 |
| Alternate Webpage(s) | http://www.tissueeng.net/lab/papers/Delivering-life-s-blood-emerging-technologies-current-opportunities-and-challenges_2014_Current-Opinion-in-Chemical-Engineering.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/j.coche.2014.01.003 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
