Loading...
Please wait, while we are loading the content...
α-Melanocyte stimulating hormone has beneficial effects on cerulein-induced acute pancreatitis
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jahovic, Nermina Arbak, Serap Tekeli, Özgür Ali̇can, İnci̇ |
| Copyright Year | 2004 |
| Abstract | Abstract We investigated the effect of α-melanocyte stimulating hormone (α-MSH) on cerulein induced acute pancreatitis in rats. α-MSH treatment (50 μg per rat, intraperitoneally) prior to cerulein reduced the plasma amylase level, pancreatic weight, pancreatic myeloperoxidase activity and the severity of the lesions microscopically. These data suggest that α-MSH has a protective effect on cerulein-induced acute pancreatitis and this effect could be attributed, at least in part, to decreased tissue leukocyte infiltration and thus, to decreased pro-inflammatory cytokine production and/or oxygen- and nitrogen-derived reactive metabolite release. |
| Starting Page | 129 |
| Ending Page | 132 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.peptides.2003.11.008 |
| Volume Number | 25 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0196978103004157 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0196978103004157?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.peptides.2003.11.008 |
| Journal | Peptides |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
