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Allergy Workup in Allergic Rhinitis at Jeddah, Saudi Arabia
| Content Provider | Semantic Scholar |
|---|---|
| Author | Koshak, Emad Abdelqader Daghistani, Kamal Jalal Jamal, Tarek S. Backer, Wadiah Saleh |
| Copyright Year | 2005 |
| Abstract | Background: Appropriate medical diagnosis and therapy of allergic rhinitis (AR) necessitate the identification of an IgE mediated sensitization to allergen. Objective: To explore the spectrum of allergy investigations in patients with AR. Settings: King Abdulaziz University Hospital (KAUH), Jeddah, Saudi Arabia. Methods: This is a prospective cross-sectional study. 41 patients with symptoms and signs compatible with AR examined at ENT clinics were sequentially included. AR diagnosis was confirmed at Allergy clinic by a positive reaction to an in-vivo skin prick test (SPT) to common inhalant allergens (sensitization). AR cases then underwent different in-vitro tests: total peripheral eosinophil count (TPEC), total serum IgE, and specific IgE antibodies to common inhalant allergens by immuno-CAP system (Phadiatop). Results: AR confirmed by positive SPT was detected in 30 cases (73%). Their ages ranged between 16 – 52 years old (mean 27 ±9SD), and females constituted 60%. The predominant allergens were house dust mites (HDMs): Dermatophagoides pteronyssinus 70 % and D. farinae 67%, Cat 33%, Cockroach 33%, Salsola pestifer 23%, and Aspergilus 20%. TPEC ranged 10-1200 cell/mm3 (mean= SD), and eosinophilia (?450 cells/mm3) was found in 23%. Total IgE ranged 8 – 2000 IU/ml (mean= SD), and was elevated (>190 IU/ml) in 47%. Phadiatop was positive in 83% of AR cases. A very significant correlation between SPT and Phadiatop (df=1, P<0.001) was found. Conclusion: The prevalence of sensitization to inhalant allergens, particularly HDMs, by both in-vivo and in-vitro methods was common in AR cases at Jeddah. The presence of eosinophilia and/or high total IgE in the context of compatible clinical findings may help in the diagnosis of AR. This work advocates the importance of allergy workup for allergen sensitization in both AR diagnosis and the subsequent care of patients by promoting avoidance strategies. |
| File Format | PDF HTM / HTML |
| Volume Number | 5 |
| Alternate Webpage(s) | https://print.ispub.com/api/0/ispub-article/4359 |
| Alternate Webpage(s) | https://doi.org/10.5580/534 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
