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Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Jeon, Young Joo Kim, Ok Joon Kim, Su Yeoun Oh, Seung-Hun Oh, Doyeun Kim, Ok Jun Shin, Byoung Soo Kim, Nam Keun |
| Copyright Year | 2013 |
| Abstract | OBJECTIVE MicroRNAs play a role in atherosclerosis-related diseases, such as cerebrovascular or cardiovascular disease. However, the effect of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms on stroke and silent brain infarction (SBI) susceptibility has not been reported. METHODS AND RESULTS Using polymerase chain reaction-amplified DNA, microRNA polymorphisms were analyzed in 678 patients with ischemic stroke, 373 patients with SBI, and 553 control subjects. The miR-146aC>G polymorphism and miR-146aG/-149T/-196a2C/-499G allele combination was significantly associated with ischemic stroke prevalence. For SBI prevalence, there were no statistically significant genetic markers. However, some allele combinations were associated with increased SBI incidence (C-T-C-G and G-T-T-A of miR-146a/-149/-196a2/-499). In subgroup analyses, miR-146aC>G increased stroke risk in female, normotensive, and nondiabetic groups. There were significant combined effects between microRNA polymorphisms and homocysteine/folate levels on ischemic stroke and SBI prevalence. CONCLUSIONS The miR-146aG allele and miR-146aG/-149T/-196a2C/-499G allele combination were associated with ischemic stroke pathogenesis. The combined effects between microRNA polymorphisms and homocysteine/folate levels may contribute to stroke and SBI prevalence. |
| Starting Page | 655 |
| Ending Page | 661 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/33/2/420.full.pdf |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/33/2/420.full.pdf?download=true |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/early/2012/11/29/ATVBAHA.112.300251.full.pdf |
| Alternate Webpage(s) | http://atvb.ahajournals.org/content/atvbaha/early/2012/11/29/ATVBAHA.112.300251.full.pdf?download=true |
| PubMed reference number | 23202363v1 |
| Alternate Webpage(s) | https://doi.org/10.1161/ATVBAHA.112.300251 |
| DOI | 10.1161/atvbaha.112.300251 |
| Journal | Arteriosclerosis, thrombosis, and vascular biology |
| Volume Number | 33 |
| Issue Number | 2 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Atherosclerosis Brain Infarction Cardiovascular Diseases Cerebral Infarction Cerebrovascular accident Folic Acid Genetic Markers Genetic Polymorphism MicroRNAs Myocardial Infarction Patients Polymerase Chain Reaction Serum-derived Bovine Immunoglobulin Protein Isolate homocysteine |
| Content Type | Text |
| Resource Type | Article |
