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HLA-DRB 1 / DQB 1 susceptibility for autoimmune polyglandular syndrome type II and III in south of Tunisia Susceptibilité HLA-DRB 1 / DQB 1 aux polyendocrinopathies auto-immunes type II et III dans le Sud tunisien
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fourati, Hela Mahfoudh, Nedia Abida, Olfa Kammoun, Arwa Mnif, Fatma Haddouk, Samy Ayed, M. Ben Hmida, Y. Ben Hadj Rekik, Noureddine Abid, Maha Makni, Hafedh Masmoudi, Hatem |
| Copyright Year | 2011 |
| Abstract | Objectives. – The aim of our study was to investigate the association of HLA-DRB1 and HLA-DQB1 alleles with autoimmune polyglandular syndromes (APS) type II and III in a southern Tunisian population. Patients and methods. – Sixty-two unrelated patients with APSII (n = 20) and APSIII (n = 42) and 146 healthy controls were genotyped for HLA class II alleles (DRB1*, DQB1*) by PCR-SSP technique. Results. – An increased frequencies of HLA-DQB1*03:02 (P = 0,02; OR = 2.98) in APSII patients, HLA-DRB1*03 (P = 3 10−6; OR = 4.28) and HLADQB1*02:01 (P = 0.04; OR = 1.95) in APSIII patients were found compared to healthy controls. Study of the HLA-DRB1*;DQB1* haplotype −3 frequencies showed a higher occurrence of DRB1*04;DQB1*03:02 and DRB1*03;DQB1*02:01 in APSII patients (P = 4 10 ; OR = 3.31 and P = 0.03; OR = 2.74 respectively) whereas APSIII was only associated with DRB1*03;DQB1*02:01 (P = 7.2 10−8, OR = 4.71). Conclusion. – Our data suggest that the variation in class II HLA alleles and haplotypes could be a genetic factor involved in the susceptibility of APS syndrome. © 2011 Elsevier Masson SAS. All rights reserved. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.em-consulte.com/showarticlefile/297230/main.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
