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Neuromuscular function in fast and slow muscles of genetically dystrophic mice
| Content Provider | Semantic Scholar |
|---|---|
| Author | Curran, M. Parry, David J. |
| Copyright Year | 1975 |
| Abstract | Abstract We have determined the frequency of miniature end plate potentials (mepps) in the extensor digitorum longus (EDL) and the soleus (SOL) muscles of normal and dystrophic mice at various ages. In the normal animal the frequencies in the two muscles are very similar soon after birth. The frequency continues to increase in the EDL to reach a level of 19.12 sec −1 while the frequency in the SOL seems to reach its adult level of 12.36 sec −1 much earlier (20–30 days). Dystrophy does not affect the frequency in the SOL but in the adult dystrophic EDL the value is significantly lower than its normal counterpart. Since this effect occurs at a later time than the onset of the symptoms of the disease we consider it to be a secondary phenomenon. This does not, however, rule out the possibility of a neurogenic defect in the etiology of murine muscular dystrophy. |
| Starting Page | 150 |
| Ending Page | 161 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0014-4886(75)90243-5 |
| PubMed reference number | 1123004 |
| Journal | Medline |
| Volume Number | 47 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0014488675902435 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0014488675902435?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0014-4886%2875%2990243-5 |
| Journal | Experimental Neurology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
