NDLI: Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis.

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Expression of complement regulatory proteins CD55, CD59, CD35, and CD46 in rheumatoid arthritis.

Content Provider	Semantic Scholar
Author	Piccoli, Amanda Kirchner Alegretti, Ana Paula Schneider, Laiana Lora, Priscila S. Xavier, Ricardo Machado
Copyright Year	2011
Abstract	Rheumatoid arthritis (RA) is an autoimmune disease associated with polyarticular inflammatory synovitis affecting mainly peripheral joints. It affects approximately 1% of the world population, being two to three times more prevalent in women. Rheumatoid arthritis has a complex and multifactorial pathogenesis. The synovium of the affected joints is infiltrated by T and B lymphocytes, macrophages, and granulocytes. The rheumatoid synovium has proliferative characteristics, forming the pannus, which invades cartilage and bone, leading to normal architecture destruction and function loss. The decreased expression of complement regulatory proteins (CRP) seems to play an important role in RA activity, and is associated with worsening of the clinical symptoms. In several models of autoimmune diseases, the overactivation of the complement system (CS) is the cause of disease exacerbation. This article aimed at reviewing the main aspects related to CS regulation in RA in order to provide a better understanding of the potential role of this system in the pathophysiology and activity of the disease.
File Format	PDF HTM / HTML
PubMed reference number	21953001
Journal	Medline
Volume Number	51
Issue Number	5
Alternate Webpage(s)	http://www.scielo.br/pdf/rbr/v51n5/en_v51n5a09.pdf
Alternate Webpage(s)	http://www.lume.ufrgs.br/bitstream/handle/10183/62551/000795272-02.pdf?sequence=2
Journal	Revista brasileira de reumatologia
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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