NDLI: Nefiracetam improves Morris water maze performance following traumatic brain injury in rats

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Nefiracetam improves Morris water maze performance following traumatic brain injury in rats

Content Provider	Semantic Scholar
Author	DeFord, S. Michelle Wilson, Margaret S. Gibson, Cynthia J. Baranova, Anya Hamm, Robert J.
Copyright Year	2001
Abstract	Nefiracetam, a pyrrolidone derivative, is a nootropic agent that has facilitated cognitive function in a wide variety of animal models of cognitive dysfunction. The purpose of this study was to investigate the efficacy of the chronic postinjury administration of nefiracetam (DM-9384) in improving cognitive performance following central fluid percussion brain injury in rats. Twenty-four hours following surgical preparation, a sham injury or a moderate fluid percussive injury (2.1 atm) was delivered. Nefiracetam was administered chronically (0 or 9 mg/kg, po, for sham animals and 0, 3, or 9 mg/kg for injured animals) on postinjury days 1-15. Cognitive performance was assessed using the Morris water maze (MWM) on postinjury days 11-15. Chronic administration of 3 and 9 mg/kg nefiracetam attenuated MWM deficits produced by central fluid percussive brain injury. Importantly, the MWM performance of the injured animals treated with 9 mg/kg did not significantly differ from uninjured, sham animals. The 9-mg/kg dose of nefiracetam did not have a positive or negative effect on MWM performance of uninjured animals. The results of the present experiment suggest that a nootropic such as nefiracetam may be an appropriate treatment for trauma-induced cognitive dysfunction.
Starting Page	611
Ending Page	616
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/S0091-3057(01)00559-7
PubMed reference number	11509223
Journal	Medline
Volume Number	69
Alternate Webpage(s)	https://www.researchgate.net/profile/Cynthia_Gibson/publication/222341298_Nefiracetam_improves_Morris_water_maze_performance_following_traumatic_brain_injury_in_rats/links/5592a82308ae5af2b0eb4d0b.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0091305701005597
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0091305701005597?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/S0091-3057%2801%2900559-7
Journal	Pharmacology Biochemistry and Behavior
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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