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Molecular modelling, synthesis and antitumour activity of carbocyclic analogues of netropsin and distamycin--new carriers of alkylating elements.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Bartulewic, D. Markowska, Agnieszka Wołczyński, Sławomir Dąbrowska, Mariola Różański, Andrzej |
| Copyright Year | 2000 |
| Abstract | A series of netropsin and distamycin analogues was synthesised and investigated by molecular modelling. The lowest-energy conformations of four carbocyclic lexitropsins, potential carriers of alkylating elements, were obtained using the HyperChem 4.0 program, and compared with the DNA-lexitropsin crystal structures from the Brookhaven National Laboratory Protein Data Bank. A method for synthesis of carbocyclic lexitropsins was elaborated, with the use of a nitro group or azobenzene as precursors for the aromatic amino group. The influence of methoxy group in ortho position with respect to amide groups on the activity of the new compounds was investigated. All of the compounds tested showed high antitumour activity in the standard cell line of mammalian tumour MCF-7. |
| Starting Page | 23 |
| Ending Page | 35 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| DOI | 10.18388/abp.2000_4059 |
| Alternate Webpage(s) | http://www.actabp.pl/pdf/1_2000/23-35.pdf |
| Alternate Webpage(s) | http://www.actabp.pl/pdf/1_2000/23.pdf |
| Alternate Webpage(s) | http://www.actabp.pl/pdf/1_2000/23-35s.pdf |
| PubMed reference number | 10961675 |
| Alternate Webpage(s) | https://doi.org/10.18388/abp.2000_4059 |
| Journal | Medline |
| Volume Number | 47 |
| Issue Number | 1 |
| Journal | Acta biochimica Polonica |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
