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Coexpression of vasoactive intestinal peptide, calcitonin gene-related peptide and substance P immunoreactivity in parasympathetic neurons of the rhesus monkey lung
| Content Provider | Semantic Scholar |
|---|---|
| Author | Nohr, Donatus Eiden, Lee E. Weihe, Elizabeth |
| Copyright Year | 1995 |
| Abstract | By the use of light microscopic immunohistochemistry, the present study investigates whether substance P (SP) and calcitonin gene-related peptide (CGRP), which are well documented neurotransmitter candidates in primary sensory fibers, are also expressed in parasympathetic neurons of the rhesus monkey lung. A combination of double fluorescence immunohistochemistry and staining of adjacent sections revealed triple coexistence of SP, CGRP and the cholinergic co-transmitter vasoactive intestinal peptide (VIP) in a large number of neuronal cell bodies in intrinsic peribronchial ganglia. In addition, there was co-localization of SP and CGRP in choline acetyl-transferase (ChAT)-positive neurons. These data suggest that SP and CGRP, in addition to their sensory role, are cholinergic cotransmitter candidates in the postganglionic parasympathetic innervation of primate lung. Co-release and co-function of SP and CGRP with VIP and acetylcholine may be important in the regulation of pulmonary physiology and in pulmonary pathophysiology. |
| Starting Page | 25 |
| Ending Page | 28 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(95)12001-K |
| PubMed reference number | 8584218 |
| Journal | Medline |
| Volume Number | 199 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/030439409512001K |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/030439409512001K?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2895%2912001-K |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
