NDLI: In Vitro Activity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States.

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In Vitro Activity of Lefamulin Tested against Streptococcus pneumoniae with Defined Serotypes, Including Multidrug-Resistant Isolates Causing Lower Respiratory Tract Infections in the United States.

Content Provider	Semantic Scholar
Author	Mendes, Rodrigo Elisandro Farrell, Desmond J. Flamm, Robert K. Talbot, George H. Ivezić-Schoenfeld, Zrinka Paukner, Susanne Pnevmatikos, Ioannis
Copyright Year	2016
Abstract	Lefamulin was evaluated against various Streptococcus pneumoniae serotypes that were collected from adults with lower respiratory tract infections. Lefamulin exhibited MIC50 and MIC90 values of 0.12 and 0.25 μg/ml, respectively, against the entire collection (n = 822). Similar results were obtained for lefamulin against each of the most common serotypes as well as against multidrug-resistant isolates and strains that are nonsusceptible to ceftriaxone or erythromycin. These data support the clinical development of lefamulin for the treatment of community-acquired respiratory tract infections.
Starting Page	447
Ending Page	458
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://aac.asm.org/content/60/7/4407.full.pdf
PubMed reference number	27161634v1
Alternate Webpage(s)	https://doi.org/10.1128/AAC.00627-16
DOI	10.1128/AAC.00627-16
Journal	Antimicrobial agents and chemotherapy
Volume Number	60
Issue Number	7
Language	English
Access Restriction	Open
Subject Keyword	Ceftriaxone Erythromycin Lower respiratory tract infection Pneumonia Respiratory Tract Infections Respiratory tract structure Serotype Streptococcus pneumoniae
Content Type	Text
Resource Type	Article

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