Influencing factors of NT-proBNP level inheart failure patients with different cardiacfunctions and correlation with prognosis

Content Provider	Semantic Scholar
Author	Xu, Liang Chen, Yanchun Ji, Yanni Yang, Song
Copyright Year	2018
Abstract	Factors influencing N-terminal pro-brain natriuretic peptide (NT-proBNP) level in heart failure patients with different cardiac functions were identified to explore the correlations with prognosis. Eighty heart failure patients with different cardiac functions treated in Yixing People's Hospital from January 2016 to June 2017 were selected, and divided into two groups (group with cardiac function in class II and below and group with cardiac function in class III and above), according to the cardiac function classification established by New York Heart Association (NYHA). Blood biochemical test and outcome analysis were conducted to measure serum NT-proBNP and matrix metalloproteinase-9 (MMP-9) levels in patients with different cardiac functions, and correlations between levels of NT-proBNP and MMP-9 and left ventricular ejection fraction (LVEF) level were analyzed in patients with different cardiac functions at the same time. In addition, risk factors for heart failure in patients with different cardiac functions were analyzed. Compared with the group with cardiac function in class III and above, the group with cardiac function in class II and below had significantly lower serum NT-proBNP and MMP-9 levels (p<0.05). For echocardiogram indexes, left ventricular end-diastolic diameter (LVEDD) and left ventricular end-systolic diameter (LVESD) in the group with cardiac function in class II and below were obviously lower than those in the group with cardiac function in class III and above (p<0.05), while LVEF was higher in group with cardiac function in class II and below than that in group with cardiac function in class III and above (p<0.05). NT-proBNP and MMP-9 levels were negatively correlated with LVEF level [r=-0.8517 and -0.8517, respectively, p<0.001 (<0.05)]. Cardiac function in class III and above, increased NT-proBNP, increased MMP-9 and decreased LVEF were relevant risk factors and independent risk factors for heart failure in patients with different cardiac functions. NT-proBNP and MMP-9 levels are negatively correlated with LVEF in patients regardless of the cardiac function class. Therefore, attention should be paid to patients who have cardiac function in class III and above, increased NT-proBNP and MMP-9 levels and decreased LVEF in clinical practices, so as to actively prevent and treat heart failure.
Starting Page	5275
Ending Page	5280
Page Count	6
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://spandidos-publications.com/etm/15/6/5275/download
PubMed reference number	5996675
Alternate Webpage(s)	https://doi.org/10.3892/etm.2018.6114
DOI	10.3892/etm.2018.6114
Journal	Experimental and therapeutic medicine
Volume Number	15
Language	English
Access Restriction	Open
Subject Keyword	Amino-terminal pro-brain natriuretic peptide Artificial cardiac pacemaker Diameter (qualifier value) Diastole Echocardiography Ejection fraction (procedure) Forecast of outcome Heart Diseases Heart failure Heart valve disease Index Left Ventricular Hypertrophy Left ventricular ejection fraction Liver Failure, Acute Matrix Metalloproteinase 9 Nesiritide Patients
Content Type	Text
Resource Type	Article