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SUMMER TRAINING AS RESEARCH SCHOLARS (STaRS) PROGRAM RESEARCH SYMPOSIUM
| Content Provider | Semantic Scholar |
|---|---|
| Author | Garcia, Diego Igwebuike, Chino |
| Copyright Year | 2014 |
| Abstract | Division of Graduate Medical Sciences, for students who are traditionally underrepresented in the biomedical sciences. Our academically talented students were selected for STaRS through a highly competitive application process and have spent the summer conducting research in labs across the BU Medical Campus. We hope you enjoy learning more about their summer research projects. The onset of asthma development begins in the early stages of life when the body is adjusting to its new environment. To study this phenomenon, my lab has specifically focused on airway epithelial cells in mouse models. The notch signaling pathway is key in cell specification and differentiation and closely linked to the growth and development of tracheal and alveolar epithelial cells. In the past, my lab has been able to construct mutated alleles for the notch1 gene and breed mice that have 32 bp tags surrounding the coding nucleic acids. A secondary gene, cre, can be induced to link to these tags and excise the coding DNA leaving the cell incapable of transcribing the full notch1 sequence. Past research has also found that children exposed to cockroach allergens during their toddler stage are predisposed to developing asthma as they grow older. My work involves analyzing in vivo and in vitro data of airway cells and organs to determine whether or not cockroach allergens do in fact interact with the notch gene and alter it in any way making it incapable of coding; and if so, is it dependent on the gene to play a role in asthma development? The in vitro study measures cytokine production variation with tracheal epithelial cells exposed to cockroach or not and involves cell staining to directly view cell differentiation. The in vivo aspect studies variation of airway function with mice exposed to cre and also determines how cockroach allergens having been introduced through the nasal airway over a period of time affect breathing ability in young mice. Introduction: Glomerular capillary hypertension (GCH) develops in response to any kidney injury associated with loss of functional kidney mass, and causes further progression of kidney damage and ultimately chronic kidney disease (CKD). CKD left untreated can worsen cardiovascular disease, and lead to end stage kidney disease and death. Previous studies have shown that renal susceptibility gene Myh9 encodes an enzyme called non muscle myosin IIA (NMIIA), which is expressed highly in podocytes found within the glomeruli. We have shown that NMIIA is responsible … |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.bumc.bu.edu/gms/files/2014/08/STaRS-Abstract-Booklet.pdf |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
