NDLI: Efficient lytic induction of kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines

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Efficient lytic induction of kaposi's sarcoma-associated herpesvirus (KSHV) by the anthracyclines

Content Provider	Semantic Scholar
Author	Kang, Hyunju Song, Jaehyung Choi, Kwangman Kim, Hyeongki Choi, Miri Lee, So-Young Kim, Chonsaeng Lee, Sang Yup Song, Moon Jung Kang, Hyojeung Back, Sung Hoon Han, Sang Bae Cho, Sungchan
Copyright Year	2014
Abstract	Lytic induction of latent Kaposi's sarcoma-associated herpesvirus (KSHV) has been considered as a therapeutic option for efficient treatment of several KSHV-associated malignancies. Here, we developed a robust high-throughput screening system that allows an easy and quantitative measurement of lytic induction of latent KSHV and discovered three anthracyclines as potent inducers from screen of FDA-approved drugs. Lytic induction of latent KSHV by three compounds was verified by the significant induction of lytic genes and subsequent production of infectious KSHV. Importantly, lytic induction by three compounds was much more efficient than that by sodium butyrate, a well-characterized inducer of KSHV lytic cycle. Mechanistically, the anthracyclines caused lytic induction of KSHV through apoptosis induced by their DNA intercalation rather than topoisomerase II inhibition. Consequently, our results clearly demonstrated a role of anthracyclines as effective lytic inducers of KSHV and also provided a molecular basis of their use for efficient treatment of diseases associated with KSHV infection.
Starting Page	8515
Ending Page	8527
Page Count	13
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.oncotarget.com/index.php?journal=oncotarget&op=download&page=article&path%5B%5D=2335&path%5B%5D=3963
PubMed reference number	25237786v1
Volume Number	5
Journal	Oncotarget
Language	English
Access Restriction	Open
Subject Keyword	Anthracyclines Apoptosis Butyrates DNA Intercalation HIV Infections Infectious Canine Hepatitis Lysis Lytic Phase SARS coronavirus Sarcoma Sodium Butyrate Topoisomerase II human herpesvirus 8
Content Type	Text
Resource Type	Article

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