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Self-renewal and cancer of the gut: two sides of a coin.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Radtke, Freddy Clevers, Hans |
| Copyright Year | 2005 |
| Abstract | The intestinal epithelium follows the paradigms of stem cell biology established for other self-renewing tissues. With a unique topology, it constitutes a two-dimensional structure folded into valleys and hills: the proliferative crypts and the differentiated villi. Its unprecedented self-renewal rate appears reflected in a high susceptibility to malignant transformation. The molecular mechanisms that control homeostatic self-renewal and those that underlie colorectal cancer are remarkably symmetrical. Here, we discuss the biology of the intestinal epithelium, emphasizing the roles played by Wnt, bone morphogenic protein, and Notch signaling cascades in epithelial self-renewal and cancer. |
| File Format | PDF HTM / HTML |
| DOI | 10.1126/science.1104815 |
| PubMed reference number | 15790842 |
| Journal | Medline |
| Volume Number | 307 |
| Issue Number | 5717 |
| Alternate Webpage(s) | https://www.hubrecht.eu/app/uploads/2017/11/1904.full_.pdf |
| Alternate Webpage(s) | http://web.stanford.edu/class/archive/cbio/cbio241/cbio241.1062/coursework/radtke2005.pdf |
| Alternate Webpage(s) | https://doi.org/10.1126/science.1104815 |
| Journal | Science |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
