NDLI: Levodopa-Carbidopa Intestinal Gel Pharmacokinetics: Lower Variability than Oral Levodopa-Carbidopa

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Levodopa-Carbidopa Intestinal Gel Pharmacokinetics: Lower Variability than Oral Levodopa-Carbidopa

Content Provider	Semantic Scholar
Author	Othman, Ahmed A. Rosebraugh, Matthew Chatamra, Krai Locke, Charles S. Dutta, Sandeep
Copyright Year	2017
Abstract	In a double-blind, double-dummy, double-titration Phase 3 trial in advanced Parkinson's disease (PD) patients, the efficacy and safety of Levodopa-carbidopa intestinal gel (LCIG) infusion were characterized relative to immediate-release oral levodopa-carbidopa (LC-oral) treatment. We present in this report the comparative pharmacokinetic profiles of LCIG and LC-oral from this pivotal study. The results presented in this report clearly demonstrate that LCIG results in lower variability and fluctuations in levodopa and carbidopa plasma concentrations compared to LC-oral. The superior pharmacokinetic profiles with LCIG were consistent with its improved efficacy compared to LC-oral as demonstrated in this study.
Starting Page	275
Ending Page	278
Page Count	4
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://content.iospress.com/download/journal-of-parkinsons-disease/jpd161042?id=journal-of-parkinsons-disease/jpd161042
PubMed reference number	28211816
Alternate Webpage(s)	https://doi.org/10.3233/JPD-161042
DOI	10.3233/jpd-161042
Journal	Journal of Parkinson's disease
Volume Number	7
Language	English
Access Restriction	Open
Subject Keyword	Carbidopa Drug Kinetics Levodopa Parkinson Disease Parkinsonian Disorders Patients Titration Method
Content Type	Text
Resource Type	Article

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