Acetylcholine encodes long-lasting presynaptic plasticity at glutamatergic synapses in the dorsal striatum after repeated amphetamine exposure.

Content Provider	Semantic Scholar
Author	Wang, Wengang Darvas, Martin Storey, Granville Paul Bamford, Ian J. Gibbs, Jeffrey T. Palmiter, Richard D. Bamford, Nigel S.
Copyright Year	2013
Abstract	Locomotion and cue-dependent behaviors are modified through corticostriatal signaling whereby short-term increases in dopamine availability can provoke persistent changes in glutamate release that contribute to neuropsychiatric disorders, including Parkinson's disease and drug dependence. We found that withdrawal of mice from repeated amphetamine treatment caused a chronic presynaptic depression (CPD) in glutamate release that was most pronounced in corticostriatal terminals with a low probability of release and lasted >50 d in treated mice. An amphetamine challenge reversed CPD via a dopamine D1-receptor-dependent paradoxical presynaptic potentiation (PPP) that increased corticostriatal activity in direct pathway medium spiny neurons. This PPP was correlated with locomotor responses after a drug challenge, suggesting that it may underlie the sensitization process. Experiments in brain slices and in vivo indicated that dopamine regulation of acetylcholine release from tonically active interneurons contributes to CPD, PPP, locomotor sensitization, and cognitive ability. Therefore, a chronic decrease in corticostriatal activity during withdrawal is regulated around a new physiological range by tonically active interneurons and returns to normal upon reexposure to amphetamine, suggesting that this paradoxical return of striatal activity to a more stable, normalized state may represent an additional source of drug motivation during abstinence.
Starting Page	8
Ending Page	8
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/33/25/10405.full.pdf
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/33/25.toc.pdf
PubMed reference number	23785153v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.0014-13.2013
DOI	10.1523/jneurosci.0014-13.2013
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	33
Issue Number	25
Language	English
Access Restriction	Open
Subject Keyword	Acetylcholine Amphetamine Behavior Dopamine Drug Dependence Glutamic Acid Interneurons Kidney Failure, Chronic Neostriatum Parkinson Disease Parkinsonian Disorders Presynaptic Terminals Sensitization (observable entity) Synapses chemosensitization/potentiation nervous system disorder
Content Type	Text
Resource Type	Article