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Disseminated intravascular coagulation in cats.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Estrin, Michael A. Wehausen, Conni E. Jessen, Carl R. Lee, Justine A. |
| Copyright Year | 2006 |
| Abstract | The purpose of this study was to describe the clinical characteristics of cats with disseminated intravascular coagulation (DIC), including associated diseases and hemostatic abnormalities, and to identify risk factors for death and treatments that potentially altered outcome. Medical records for cats with DIC from 1990-2004 were evaluated retrospectively. Inclusion criteria were the presence of an underlying disorder associated with DIC and either postmortem examination findings of intravascular fibrin deposition or thrombosis, or both of 2 or more organs or coagulation profiles that meet 3 of 5 criteria: prolonged prothrombin time (PT), activated partial thromboplastin time (aPTT), presence of fibrin degradation products (FDP), low plasma fibrinogen (FIB) concentration, and thrombocytopenia (<160,000 platelets/microL). Signalment, historical data, clinical findings, clinicopathologic data, underlying disorders, management, and outcome were recorded. Forty-six cats fulfilled the criteria for DIC. Cats ranged in age from 7 weeks to 17 years (median, 9 years). Hemorrhage was noted in 7 of 46 cats (15%). Three of 46 cats (7%) survived, whereas 43 of 46 (93%) died or were euthanized. The most common underlying disorders were lymphoma, other forms of neoplasia, pancreatitis, and sepsis. There was no association detected between outcome and signalment; underlying disease; hemorrhage; abnormalities in aPTT, FIB, FDPs, platelet count; transfusion of blood products; and heparin therapy. However, the median PT of nonsurvivors was more prolonged than in survivors (P < .005). DIC in cats can result from a variety of neoplastic, infectious, and inflammatory disorders, and is associated with a high case fatality rate. |
| Starting Page | 9578 |
| Ending Page | 9593 |
| Page Count | 16 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://confluence.cornell.edu/download/attachments/325584697/Unknown%20-%20Estrin%20et%20al.%20-%20Disseminated%20intravascular%20coagulation%20in%20cats(2).pdf?api=v2&modificationDate=1448032371000&version=1 |
| PubMed reference number | 17186846v1 |
| Volume Number | 20 |
| Issue Number | 6 |
| Journal | Journal of veterinary internal medicine |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Activated Partial Thromboplastin Time measurement Autopsy Blood Coagulation Factor Blood Transfusion Blood product Cessation of life Congenital Abnormality Disseminated Intravascular Coagulation FDPS gene Fibrin split products Hemorrhage Lymphoma Neoplasms Organ Pancreatitis Platelet Count measurement Prothrombin time assay Sepsis Signs and Symptoms Survivors Temporomandibular Joint Disorders Thrombocytopenia Thrombosis Tissue Factor fibrinogen complex location heparin |
| Content Type | Text |
| Resource Type | Article |
