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Inclusion complexes of poorly water-soluble drugs with glucosyl-cyclodextrins.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Koizumi, Kyoko Okada, Yoshio Kubota, Yasuo Utamura, T. |
| Copyright Year | 1987 |
| Abstract | glucosyl-ƒ¿-CD (G-ƒ¿-CD), 6-O-ƒ¿-D-glucosyl-ƒÀ-CD (G-ƒÀ-CD), and 6A,6D-di-O-ƒ¿-D-glucosyl-ƒÀ-CD (2G-ƒÀ-CD) with slightly soluble or insoluble drugs in aqueous solution and in the solid state was studied by the solubility method, ultraviolet spectroscopy, and differential scanning calorimetry. These glucosyl-CDs were capable of forming inclusion complexes with compounds which can form complexes with the parent CDs. The enhancement of solubility of poorly water-soluble drugs by glucosyl-ƒÀ-CDs was much more marked than that by fl-CD. The hemolytic activity of glucosyl-CD was lower than that of each parent CD. The estriol—glucosyl-ƒÀ-CD complex may be practically applicable to injectable preparations because of its high water-solubility and low hemolytic activity. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.jstage.jst.go.jp/article/cpb1958/35/8/35_8_3413/_pdf |
| PubMed reference number | 3427720v1 |
| Volume Number | 35 |
| Issue Number | 8 |
| Journal | Chemical & pharmaceutical bulletin |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | CD-ROM Calorimetry Calorimetry, Differential Scanning Compact discs Cyclodextrins Diabetes Insipidus Estriol Flumazenil Gaucher Disease Hemolysis (disorder) |
| Content Type | Text |
| Resource Type | Article |
