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Choroidal malignant melanoma in an albino.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Casswell, Anthony G. McCartney, Alison C. E. Hungerford, John L. |
| Copyright Year | 1989 |
| Abstract | This is the first report of an amelanotic melanoma arising in the unpigmented choroid of a tyrosinase-positive oculocutaneous albino (TPOCA). Melanosomes within the tumour showed a maturation arrest in the unpigmented type II (premelanosome) phase. Other neural crest derived melanocytes in iris and choroid showed similar limited melanogenesis. The neuroectodermally derived melanocytes of the iris, ciliary body, and retinal pigment epithelium (RPE) contained mature melanosomes, though clinically the RPE was pale. The significance of this tumour arising in an albinotic eye is discussed. |
| Starting Page | 75 |
| Ending Page | 80 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://bjo.bmj.com/content/bjophthalmol/73/10/840.full.pdf |
| PubMed reference number | 2818996v1 |
| Volume Number | 73 |
| Issue Number | 10 |
| Journal | The British journal of ophthalmology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Biologic Development Ciliary Body Contain (action) Cutaneous Melanoma Malignant melanoma of choroid Melanoma, Amelanotic Melanosomes Neoplasms Neural Crest Retina Retinal Pigments melanocyte |
| Content Type | Text |
| Resource Type | Article |