NDLI: The involvement of ventral tegmental area cholinergic muscarinic receptors in classically conditioned fear expression as measured with fear-potentiated startle

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The involvement of ventral tegmental area cholinergic muscarinic receptors in classically conditioned fear expression as measured with fear-potentiated startle

Content Provider	Semantic Scholar
Author	Greba, Quentin Munro, Laurie J. Kokkinidis, Larry
Copyright Year	2000
Abstract	Accumulating evidence suggests that dopamine (DA) neurons in the ventral tegmental area (VTA) contribute to the complex amygdala-based neurocircuitry that mediates fear-motivated behaviors. Because of acetylcholine's (ACh) role in DA neuronal activation, the involvement of VTA cholinergic muscarinic receptors in Pavlovian conditioned fear responding was evaluated in the present study. Fear-potentiated startle was used to assess the effects of intraVTA infused methylscopolamine on conditioned fear performance in laboratory rats. Application of this nonspecific muscarinic receptor antagonist to VTA neurons was observed to inhibit the ability of a conditioned stimulus (CS) previously paired with footshock to enhance the amplitude of the acoustic startle reflex. Doses of methylscopolamine that blocked conditioned fear expression did not alter baseline sensorimotor responding. These results identify ACh neurotransmission in the VTA as a potential excitatory mechanism underlying the fear-arousing properties of threatening environmental stimuli.
Starting Page	135
Ending Page	141
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1016/S0006-8993(00)02414-8
Alternate Webpage(s)	http://www.nzbri.org/research/publications/papers/0104.pdf
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0006899300024148
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0006899300024148?dgcid=api_sd_search-api-endpoint
PubMed reference number	10869510
Alternate Webpage(s)	https://doi.org/10.1016/S0006-8993%2800%2902414-8
Journal	Medline
Volume Number	870
Journal	Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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