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Assessment of left ventricular diastolic function with three dimensional cardiac magnetic resonance imaging
| Content Provider | Semantic Scholar |
|---|---|
| Author | Fonseca, Carissa G. |
| Copyright Year | 2004 |
| Abstract | Measurement of diastolic left ventricular (LV) function is vitally important in the assessment of cardiac disease. However, only limited information on tissue function can be obtained with current clinical techniques. This Thesis developed and investigated novel parameters of both global and regional myocardial function, using cardiac magnetic resonance imaging (MRI) with three-dimensional tissue tagging. Multidirectional peak myocardial shortening strains and strain rates, as well as the peak systolic displacement and velocity of the mitral valve annulus plane (MVP), were considered as parameters of LV systolic function. The corresponding peak diastolic strain relaxation rates and peak diastolic MVP velocity were used to assess diastolic function. The effects of normal ageing were studied in people with no evidence of cardiac disease, and compared with the effects of disease in patients with type 2 diabetes mellitus (DM). In normal healthy subjects, systolic strain parameters were preserved, while diastolic parameters were impaired, with age. DM patients showed impaired diastolic function on correction for age, and systolic functional parameters were also impaired, even though LV ejection fraction was normal. MVP systolic and diastolic motion were reduced both with age and in DM patients. Systolic LV torsion was increased with age and in DM, with no corresponding increase in torsional relaxation. Both systolic and diastolic function parameters were regionally heterogeneous. With normal ageing, diastolic function was impaired in a regionally non-uniform manner. Thus, a complete assessment of LV function requires measurement of LV tissue mechanics as well as chamber haemodynamics. MRI provides valuable information regarding myocardial tissue behaviour, contributing to systolic and/or diastolic dysfunction, which cannot be obtained otherwise. Systolic tissue dysfunction may develop concomitantly in patients with diastolic dysfunction, even when global ejection fraction is preserved. Regional analyses provide important information on how local changes contribute to global function. The influence of age must be taken into account in studies of disease. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://researchspace.auckland.ac.nz/bitstream/handle/2292/5715/01front.pdf?sequence=1 |
| Alternate Webpage(s) | https://researchspace.auckland.ac.nz/bitstream/handle/2292/5715/02whole.pdf?sequence=2 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
