Fresh versus frozen embryo transfer after gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone antagonist cycles among high responder women: A randomized, multi-center study

Content Provider	Semantic Scholar
Author	Aflatoonian, Abbas Mansoori-Torshizi, Mahnaz Mojtahedi, Maryam Farid Aflatoonian, Behrouz Khalili, Mohammaad Ali Amir-Arjmand, Mohammad Hossein Soleimani, Mehrdad Aflatoonian, Nastaran Oskouian, Homa Tabibnejad, Nasim Humaidan, Peter S. H.
Copyright Year	2018
Abstract	Background The use of embryo cryopreservation excludes the possible detrimental effects of ovarian stimulation on the endometrium, and higher reproductive outcomes following this policy have been reported. Moreover, gonadotropin-releasing hormone agonist trigger in gonadotropin-releasing hormone (GnRH) antagonist cycles as a substitute for standard human chorionic gonadotropin trigger, minimizes the risk of ovarian hyperstimulation syndrome (OHSS) in fresh as well as frozen embryo transfer cycles (FET). Objective To compare the reproductive outcomes and risk of OHSS in fresh vs frozen embryo transfer in high responder patients, undergoing in vitro fertilization triggered with a bolus of GnRH agonist. Materials and Methods In this randomized, multi-centre study, 121 women undergoing FET and 119 women undergoing fresh ET were investigated as regards clinical pregnancy as the primary outcome and the chemical pregnancy, live birth, OHSS development, and perinatal data as secondary outcomes. Results There were no significant differences between FET and fresh groups regarding chemical (46.4% vs. 40.2%, p=0.352), clinical (35.8% vs. 38.3%, p=0.699), and ongoing (30.3% vs. 32.7%, p=0.700) pregnancy rates, also live birth (30.3% vs. 29.9%, p=0.953), perinatal outcomes, and OHSS development (35.6% vs. 42.9%, p=0.337). No woman developed severe OHSS and no one required admission to hospital. Conclusion Our findings suggest that GnRHa trigger followed by fresh transfer with modified luteal phase support in terms of a small human chorionic gonadotropin bolus is a good strategy to secure good live birth rates and a low risk of clinically relevant OHSS development in in vitro fertilization patients at risk of OHSS.
Starting Page	9
Ending Page	18
Page Count	10
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://journals.ssu.ac.ir/ijrmnew/article-1-944-en.pdf%20
Alternate Webpage(s)	http://journals.ssu.ac.ir/ijrmnew/article-1-944-en.pdf
PubMed reference number	5899765
Volume Number	16
Journal	International journal of reproductive biomedicine
Language	English
Access Restriction	Open
Subject Keyword	Birth Rate Cryopreservation Embryo transfer (procedure) Fertilization Gonadorelin Gonadotropins Human Chorionic Gonadotropin Luteal Phase Luteinizing Hormone-releasing Hormone Agonist Numerous Ovarian Hyperstimulation Syndrome Patients Peri-Implantational Loss Pregnancy Rate Receptors, LH Reproduction deslorelin ovarian neoplasm
Content Type	Text
Resource Type	Article