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Long-term alterations in peripheral taste responses to NaCl in adult rats following neonatal chorda tympani transection.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Martin, Louis J. Sollars, Suzanne I. |
| Copyright Year | 2015 |
| Abstract | The peripheral taste system of the adult rodent is highly resilient against damage, with morphological, behavioral, and functional recovery evident after regeneration of a transected nerve. If chorda tympani transection (CTX) occurs at early postnatal ages however, the nerve fails to regenerate and effects on tongue morphology and behavior are more severe and longer-lasting compared to adult denervation. To examine whether neonatal CTX induces functional changes in intact nerves, whole-nerve electrophysiology was performed on the glossopharyngeal (GL) and chorda tympani (CT) nerves of adult rats that received CTX at P10. Attenuation of NaCl-elicited GL responses were observed in CTX rats 2 months after surgery, with bilateral denervation causing the largest decreases in responses. When assessed 1 year after neonatal CTX, amiloride-sensitive responses to NaCl in the contralateral CT increased while amiloride-insensitive responses decreased. Responses to other tastants were consistent with control animals. This is the first evidence of long-term functional changes to the peripheral taste system after injury in rats fed a normal diet. This study further characterizes the developing peripheral taste system as highly susceptible to change following neural injury. |
| Starting Page | 97 |
| Ending Page | 108 |
| Page Count | 12 |
| File Format | PDF HTM / HTML |
| DOI | 10.1093/chemse/bju063 |
| PubMed reference number | 25537015 |
| Journal | Medline |
| Volume Number | 40 |
| Issue Number | 2 |
| Alternate Webpage(s) | http://chemse.oxfordjournals.org/content/40/2/97.full.pdf |
| Alternate Webpage(s) | https://doi.org/10.1093/chemse%2Fbju063 |
| Journal | Chemical senses |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
