Nitric oxide synthase inhibitors prevent apomorphine- and oxytocin-induced penile erection and yawning in male rats

Content Provider	Semantic Scholar
Author	Melis, Maria Rosaria Argiolas, Antonio
Copyright Year	1993
Abstract	The effect of NG-nitro-L-arginine methyl ester and NG-monomethyl-L-arginine, two inhibitors of nitric oxide synthase, on apomorphine- and oxytocin-induced penile erection and yawning, was studied in male rats after intravenous and intracerebroventricular administration. Both compounds prevented dose-dependently apomorphine and oxytocin responses, when given systemically (5-50 mg/kg) or centrally (30-500 micrograms per rat), but NG-nitro-L-arginine methyl ester was about 5 times more potent than NG-monomethyl-L-arginine. The D-isomer of NG-monomethyl-L-arginine, which does not inhibit nitric oxide synthase, was ineffective. The results suggest that central nitric oxide is involved in the expression of penile erection and yawning induced by apomorphine and oxytocin.
Starting Page	71
Ending Page	74
Page Count	4
File Format	PDF HTM / HTML
DOI	10.1016/0361-9230(93)90321-2
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0361923093903212
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0361923093903212?dgcid=api_sd_search-api-endpoint
PubMed reference number	7686437
Alternate Webpage(s)	https://doi.org/10.1016/0361-9230%2893%2990321-2
Journal	Medline
Volume Number	32
Journal	Brain Research Bulletin
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article