NDLI: Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia.

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Inhibition of coagulation, fibrinolysis, and endothelial cell activation by a p38 mitogen-activated protein kinase inhibitor during human endotoxemia.

Content Provider	Semantic Scholar
Author	Branger, Judith Blink, Bernt Van Den Weijer, Sebastiaan Gupta, Abhya Peppelenbosch, Maikel P.
Copyright Year	2003
Abstract	P38 mitogen-activated protein kinase (MAPK) is an important component of intracellular signaling cascades that initiate various inflammatory cellular responses. To determine the role of p38 MAPK in the procoagulant response to lipopolysaccharide (LPS), 24 healthy subjects were exposed to an intravenous dose of LPS (4 ng/kg), preceded 3 hours earlier by orally administered 600 or 50 mg BIRB 796 BS (a specific p38 MAPK inhibitor), or placebo. The 600-mg dose of BIRB 796 BS strongly inhibited LPS-induced coagulation activation, as measured by plasma concentrations of the prothrombin fragment F1 + 2. BIRB 796 BS also dose dependently attenuated the activation and subsequent inhibition of the fibrinolytic system (plasma tissue-type plasminogen activator, plasmin-alpha2-antiplasmin complexes, and plasminogen activator inhibitor type 1) and endothelial cell activation (plasma soluble E-selectin and von Willebrand factor). Activation of p38 MAPK plays an important role in the procoagulant and endothelial cell response after in vivo exposure to LPS.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://bloodjournal.hematologylibrary.org/content/early/2003/02/06/blood-2002-11-3338.full.pdf
Alternate Webpage(s)	http://www.bloodjournal.org/content/bloodjournal/101/11/4446.full.pdf?sso-checked=true
PubMed reference number	12576315v1
Volume Number	101
Issue Number	11
Journal	Blood
Language	English
Access Restriction	Open
Subject Keyword	E-Selectin Endothelial Cells Fibrinolysis Lipopolysaccharides Mitogen-Activated Protein Kinase Inhibitor Mitogen-Activated Protein Kinases Mitogens Oral cavity Plasmin Protein Kinase Inhibitors SERPINE1 protein, human Selectins Thrombolytic Therapy alteplase fat-soluble vitamin response to lipopolysaccharide
Content Type	Text
Resource Type	Article

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