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Minimally invasive screening for colitis using attenuated total internal reflectance fourier transform infrared spectroscopy.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Titus, Jitto Viennois, Emilie Merlin, Didier Perera, A. G. Unil |
| Copyright Year | 2017 |
| Abstract | This article describes a rapid, simple and cost-effective technique that could lead to a screening method for colitis without the need for biopsies or in vivo measurements. This screening technique includes the testing of serum using Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy for the colitis-induced increased presence of mannose. Chronic (Interleukin 10 knockout) and acute (Dextran Sodium Sulphate-induced) models for colitis are tested using the ATR-FTIR technique. Arthritis (Collagen Antibody Induced Arthritis) and metabolic syndrome (Toll like receptor 5 knockout) models are also tested as controls. The marker identified as mannose uniquely screens and distinguishes the colitic from the non-colitic samples and the controls. The reference or the baseline spectrum could be the pooled and averaged spectra of non-colitic samples or the subject's previous sample spectrum. This shows the potential of having individualized route maps of disease status, leading to personalized diagnosis and drug management. |
| Starting Page | 465 |
| Ending Page | 472 |
| Page Count | 8 |
| File Format | PDF HTM / HTML |
| DOI | 10.1002/jbio.201600041 |
| PubMed reference number | 27094092 |
| Journal | Medline |
| Volume Number | 10 |
| Issue Number | 3 |
| Alternate Webpage(s) | http://physics.gsu.edu/perera/papers/Minimally%20invasive%20screening%20for%20colitis%20using%20attenuated..pdf |
| Alternate Webpage(s) | http://physics.gsu.edu/perera/papers/Minimally%20invasive%20screening%20for%20colitis%20using%20attenuated.pdf |
| Alternate Webpage(s) | https://doi.org/10.1002/jbio.201600041 |
| Journal | Journal of biophotonics |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
