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Analisi dei fattori correlati alla mortalità di una coorte di pazienti con ictus ischemico acuto
| Content Provider | Semantic Scholar |
|---|---|
| Author | Caldarola, Chiara Gadaleta Martignoni, A. Benedicti, Elisa Falaschi, Francesco Lanzarini, Luca Preti, Paola Savioli, Gabriele Sarnelli, Maria Francesca Tinelli, Carmine Carugno, B. Fratti, Cesare |
| Copyright Year | 2010 |
| Abstract | Aim of the study. To evaluate the factors associated with mortality in the short term (30 days) or medium-long term (30 days conditional mortality as mortality at the end of follow-up, excluding deaths occurring within 30 days) in a patient cohort with acute ischemic stroke. Materials and methods. This study includes 331 patients with acute ischemic stroke, living in the area of the Local Health Authority of Pavia, admitted to the Stroke Unit between 1/10/2004 and 31/12/2008. Risk factors were assessed for each patient along with instrumental and laboratory data, co morbidities and complications, therapy, stroke subtype and clinical outcome. The neurological deficit was measured using the National Insti-tute of Health Stroke Scale (NIHSS); the disability was measured with the Rankin scale (mRS). Mortality data were derived completely from data of Pavia Local Health Authority. Results. The in-hospital mortality of the whole cohort was 7% (average in hospital stay 12±6 days, median 12); within 30 days of the event the mortality was 10%, at three months it was 18% and after one year it was 27%. At the end of follow-up (30/06/2009) a total of 119 patients had died (36%). Predictors of 30-day mortality in the univariate analysis are: age, NIHSS, fever, presence of lower respiratory tract infection, detectable on admission to hospital or hospital-acquired, bladder catheterization and any kind of atrial fibrillation (FA). Antihypertensive and antiplatelet therapies at discharge correlate with a reduction of the risk of death. Predic-tors of mortality in the medium-long term are: age, length of hospitalization, NIHSS, fever, bladder catheterization, lower respiratory tract infection, history of FA and an increased degree of disability. However, antiplatelet and statin therapies play a protective role. Multivariate analysis showed that age and maximum value of NIHSS are independent factors of the risk of short-term death. In the medium-long term independent predictors of mortality are: age, length of hospitalization, degree of disability at discharge, and lower respiratory tract infections. Conclusions. Survival at 30 days and in the medium-long term were conditioned by: age, NIHSS, history of FA, lower respiratory tract infections, fever and cardio-embolic stroke subtype. Antiplatelet and statin therapies are associated with a better prognosis. |
| Starting Page | 219 |
| Ending Page | 227 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| DOI | 10.6092/2039-1404.123.599 |
| Volume Number | 123 |
| Alternate Webpage(s) | http://riviste.paviauniversitypress.it/index.php/bsmc/article/download/599/583 |
| Alternate Webpage(s) | https://doi.org/10.6092/2039-1404.123.599 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
